167887-97-0
Chemical Structure
Olamufloxacin
Synonym(s): HSR-903 free base
- CAS No.: 167887-97-0
- Formula:C20H23FN4O3
- Molecular Weight:386.43
IUPAC Name: (S)-5-amino-7-(7-amino-5-azaspiro[2.4]heptan-5-yl)-1-cyclopropyl-6-fluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
InChIKey: LEILBPMISZFZQK-GFCCVEGCSA-N
SMILES: N[C@H]1C2(CN(C1)C=3C(C)=C4N(C=C(C(O)=O)C(=O)C4=C(N)C3F)C5CC5)CC2
Biological Activity: Olamufloxacin (HSR-903) is an orally active fluoroquinolone antibacterial agent. Olamufloxacin inhibits DNA supercoiling activity. Olamufloxacin exhibits activity against Gram-positive, Gram-negative, chlamydial, and quinolone-resistant bacterial strains. Olamufloxacin can be used for the research of bacterial infections[1][2][3][4][5].
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Olamufloxacin | Olamufloxacin (HSR-903) is an orally active fluoroquinolone antibacterial agent. Olamufloxacin inhibits DNA supercoiling activity. Olamufloxacin exhibits activity against Gram-positive, Gram-negative, chlamydial, and quinolone-resistant bacterial strains. Olamufloxacin can be used for the research of bacterial infections. | |||||||||||||||||||||
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- [1]. Yoshizumi S, et al. The in vivo activity of olamufloxacin (HSR-903) in systemic and urinary tract infections in mice. J Antimicrob Chemother. 2001;48(1):137-140. [Content Brief]
- [2]. Takahashi Y, et al. In vitro activity of HSR-903, a new quinolone. Antimicrob Agents Chemother. 1997;41(6):1326-1330. [Content Brief]
- [3]. Yoshizumi S, et al. In vivo activity of HSR-903, a new fluoroquinolone, against respiratory pathogens. Antimicrob Agents Chemother. 1998;42(4):785-788. [Content Brief]
- [4]. Niki Y, et al. In vitro and in vivo antichlamydial activities of HSR-903, a new fluoroquinolone antibiotic. Antimicrob Agents Chemother. 1997;41(4):857-859. [Content Brief]
- [5]. Deguchi T, et al. In-vitro antimicrobial activity of HSR-903, a new fluoroquinolone, against clinical isolates of Neisseria gonorrhoeae with quinolone resistance-associated alterations in GyrA and ParC. J Antimicrob Chemother. 1997;40(3):437-439. [Content Brief]
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