173424-77-6
173424-77-6
Chemical Structure
Laromustine
Synonym(s): VNP40101M
- CAS No.: 173424-77-6
- Formula:C6H14ClN3O5S2
- Molecular Weight:307.78
IUPAC Name: 2-(2-chloroethyl)-N-methyl-1,2-bis(methylsulfonyl)hydrazinecarboxamide
InChIKey: PVCULFYROUOVGJ-UHFFFAOYSA-N
SMILES: O=C(N(S(=O)(C)=O)N(S(=O)(C)=O)CCCl)NC
Biological Activity: Laromustine (VNP40101M) is a compound with antitumor activity. The mechanism of action of Laromustine mainly involves DNA alkylation and DNA repair inhibition. Laromustine can be used for bone marrow transplantation in patients with acute myeloid leukemia and cancer[1].
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Laromustine | 99.74% | Laromustine (VNP40101M) is a compound with antitumor activity. The mechanism of action of Laromustine mainly involves DNA alkylation and DNA repair inhibition. Laromustine can be used for bone marrow transplantation in patients with acute myeloid leukemia and cancer. | ||||||||||||||||||||
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References
- [1]. Nassar A E F, et al. An in vitro evaluation of the victim and perpetrator potential of the anticancer agent laromustine (VNP40101M), based on reaction phenotyping and inhibition and induction of cytochrome P450 enzymes[J]. Drug metabolism and disposition, 2009, 37(9): 1922-1930. [Content Brief]
Keywords
