174568-68-4
Chemical Structure
Tetramethylrhodamine-6-maleimide
- CAS No.: 174568-68-4
- Formula:C28H23N3O5
- Molecular Weight:481.50
IUPAC Name: 2-(3,6-bis(dimethylamino)xanthylium-9-yl)-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate
InChIKey: SHKRXDBVQOSKJN-UHFFFAOYSA-N
SMILES: CN(C1=CC2=[O+]C3=C(C=CC(N(C)C)=C3)C(C4=C(N5C(C=CC5=O)=O)C=CC=C4C([O-])=O)=C2C=C1)C
Biological Activity: Tetramethylrhodamine-6-maleimide is a fluorescent dye with a reactive sulfhydryl-specific moiety is covalently coupled to this cysteine. Tetramethylrhodamine-6-maleimide can be used as labels to detect local protein motions of the fully active Na+/K+-ATPase in real time[1][2].
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Tetramethylrhodamine-6-maleimide | Tetramethylrhodamine-6-maleimide is a fluorescent dye with a reactive sulfhydryl-specific moiety is covalently coupled to this cysteine. Tetramethylrhodamine-6-maleimide can be used as labels to detect local protein motions of the fully active Na+/K+-ATPase in real time. | |||||||||||||||||||||
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- [1]. Geibel S, et al. Conformational dynamics of the Na+/K+-ATPase probed by voltage clamp fluorometry. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):964-9. [Content Brief]
- [2]. Loo DD, et al. Conformational changes couple Na+ and glucose transport. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7789-94. [Content Brief]
Keywords
