174689-39-5
174689-39-5
Chemical Structure
SR59230A
- CAS No.: 174689-39-5
- Formula:C23H29NO6
- Molecular Weight:415.48
IUPAC Name: (S)-1-(2-ethylphenoxy)-3-(((S)-1,2,3,4-tetrahydronaphthalen-1-yl)amino)propan-2-ol oxalate
InChIKey: XTBQNQMNFXNGLR-MKSBGGEFSA-N
SMILES: O[C@@H](CN[C@H]1CCCC2=C1C=CC=C2)COC3=CC=CC=C3CC.O=C(O)C(O)=O
Biological Activity: SR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist[1] with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively[2].
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SR59230A | 98.0% | SR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively. | ||||||||||||||||||||
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SR59230A (Standard) | ≥98% | SR59230A (Standard) is the analytical standard of SR59230A (HY-100672). This product is intended for research and analytical applications. SR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively. | ||||||||||||||||||||
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References
- [1]. Nisoli E, et al. Functional studies of the first selective beta 3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes.Mol Pharmacol. 1996 Jan;49(1):7-14. [Content Brief]
- [2]. Kanzler SA, et al. Involvement of β3-adrenergic receptors in the control of food intake in rats.Braz J Med Biol Res. 2011 Nov;44(11):1141-7. [Content Brief]
Keywords
