175521-95-6
Chemical Structure
AGN 192403
Synonym(s): (+)-BRD4780 free base
- CAS No.: 175521-95-6
- Formula:C10H19N
- Molecular Weight:153.26
IUPAC Name: (1S,2S,3S,4R)-3-isopropylbicyclo[2.2.1]heptan-2-amine
InChIKey: SHXVJSFOJHMEEQ-KATARQTJSA-N
SMILES: CC([C@H]1[C@@]2([H])C[C@@](CC2)([H])[C@@H]1N)C
Biological Activity: AGN 192403 (BRD4780) is a potent and selective imidazoline-1 receptor antagonist with a Ki value of 42 nM. AGN 192403 is also a TMED9 inhibitor. AGN 192403 shows protective effects on oxidative cytotoxicity and mitochondrial inhibitor-induced cytotoxicity in astrocytes. AGN 192403 mitigates the proliferation and migration of differentiated glioma tumor cells. AGN 192403 can be used for glioma tumor and neurological diseases research[1][2].
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AGN 192403 | AGN 192403 (BRD4780) is a potent and selective imidazoline-1 receptor antagonist with a Ki value of 42 nM. AGN 192403 is also a TMED9 inhibitor. AGN 192403 shows protective effects on oxidative cytotoxicity and mitochondrial inhibitor-induced cytotoxicity in astrocytes. AGN 192403 mitigates the proliferation and migration of differentiated glioma tumor cells. AGN 192403 can be used for glioma tumor and neurological diseases research. | |||||||||||||||||||||
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- [1]. Choi DH, et al. Protective effects of rilmenidine and AGN 192403 on oxidative cytotoxicity and mitochondrial inhibitor-induced cytotoxicity in astrocytes. Free Radic Biol Med. 2002 Nov 15;33(10):1321-33. [Content Brief]
- [2]. Daoud Sarsour A, et al. Targeting the Cargo Receptor TMED9 as a Therapeutic Strategy Against Brain Tumors. Cells. 2025 May 23;14(11):772. [Content Brief]
Keywords
