1776944-03-6
1776944-03-6
Chemical Structure
GEBR-7b
- CAS No.: 1776944-03-6
- Formula:C21H30N2O5
- Molecular Weight:390.47
IUPAC Name: (E)-3-(cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime
InChIKey: JEXHQZPMUKFOIV-SSDVNMTOSA-N
SMILES: COC1=CC=C(C=C1OC2CCCC2)/C=N/OCC(N3CC(C)OC(C)C3)=O
Biological Activity: GEBR-7b is a selective PDE4D inhibitor with an IC50 of 0.67 μM. GEBR-7b increases hippocampal cAMP and does not influence Aβ levels in rodents. GEBR-7b also improves spatial and can be used for the study of cognitive deficits[1][2].
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GEBR-7b | GEBR-7b is a selective PDE4D inhibitor with an IC50 of 0.67 μM. GEBR-7b increases hippocampal cAMP and does not influence Aβ levels in rodents. GEBR-7b also improves spatial and can be used for the study of cognitive deficits. | |||||||||||||||||||||
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References
- [1]. Bruno O, et al. New selective phosphodiesterase 4D inhibitors differently acting on long, short, and supershort isoforms. J Med Chem. 2009 Nov 12;52(21):6546-57. [Content Brief]
- [2]. Bruno O, et al. GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses. Br J Pharmacol. 2011 Dec;164(8):2054-63. [Content Brief]
Keywords
