1786412-46-1
Chemical Structure
L-803087 TFA
- CAS No.: 1786412-46-1
- Formula:C27H30F5N5O5
- Molecular Weight:599.55
IUPAC Name: methyl (4-(5,7-difluoro-2-phenyl-1H-indol-3-yl)butanoyl)-L-argininate 2,2,2-trifluoroacetate
InChIKey: IIRYZHRNVKQVGQ-BDQAORGHSA-N
SMILES: FC(F)(C(O)=O)F.N=C(N)NCCC[C@@H](C(OC)=O)NC(CCCC1=C(C2=CC=CC=C2)NC3=C1C=C(F)C=C3F)=O
Biological Activity: L-803087 TFA is a potent and selective somatostatin sst4 receptor agonist with a Ki of 0.7 nM. L-803087 TFA is >280-fold more selective for sst4 receptor than other somatostatin receptors. L-803087 TFA facilitates AMPA-mediated hippocampal synaptic responses in vitro and increases kainate-induced seizures in mice[1][2].
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L-803087 TFA | L-803087 TFA is a potent and selective somatostatin sst4 receptor agonist with a Ki of 0.7 nM. L-803087 TFA is >280-fold more selective for sst4 receptor than other somatostatin receptors. L-803087 TFA facilitates AMPA-mediated hippocampal synaptic responses in vitro and increases kainate-induced seizures in mice. | |||||||||||||||||||||
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- [1]. Rohrer SP, et al. Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science. 1998 Oct 23;282(5389):737-40. [Content Brief]
- [2]. Moneta D, et al. Somatostatin receptor subtypes 2 and 4 affect seizure susceptibility and hippocampal excitatory neurotransmission in mice. Eur J Neurosci. 2002 Sep;16(5):843-9. [Content Brief]
Keywords
