179388-65-9
179388-65-9
Chemical Structure
AH 11110A
- CAS 番号: 179388-65-9
- Formula:C21H27ClN2O2
- Molecular Weight:374.90
IUPAC Name: 1-([1,1'-biphenyl]-2-yloxy)-4-imino-4-(piperidin-1-yl)butan-2-ol hydrochloride
InChIKey: WWHGFIXWBLHHQB-UHFFFAOYSA-N
SMILES: OC(CC(N1CCCCC1)=N)COC2=C(C3=CC=CC=C3)C=CC=C2.Cl
Biological Activity: AH 11110A is an α1B-adrenoceptor antagonist, but it can't effectively distinguish between the different subtypes of alpha(1) adrenoceptors (A, B, and D), nor can it clearly differentiate between alpha(1) and alpha(2) adrenoceptors[1][2].
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AH 11110A | AH 11110A is an α1B-adrenoceptor antagonist, but it can't effectively distinguish between the different subtypes of alpha(1) adrenoceptors (A, B, and D), nor can it clearly differentiate between alpha(1) and alpha(2) adrenoceptors. | |||||||||||||||||||||
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References
- [1]. M Eltze, et al. Failure of AH11110A to functionally discriminate between alpha(1)-adrenoceptor subtypes A, B and D or between alpha(1)- and alpha(2)-adrenoceptors. Eur J Pharmacol. 2001 Mar;415(2-3):265-76. [Content Brief]
- [2]. Hua Zhang, et al. Different alpha-adrenoceptors mediate migration of vascular smooth muscle cells and adventitial fibroblasts in vitro. Am J Physiol Heart Circ Physiol. 2002 Jun;282(6):H2364-70. [Content Brief]
Keywords
