1799548-33-6
Chemical Structure
OAT-177
- CAS No.: 1799548-33-6
- Formula:C19H29ClN6
- Molecular Weight:376.93
IUPAC Name: 1-(3-amino-1H-1,2,4-triazol-5-yl)-N-(4-chlorophenethyl)-N-isobutylpiperidin-4-amine
InChIKey: BADSWYIEDNZIEB-UHFFFAOYSA-N
SMILES: CC(C)CN(CCC1=CC=C(Cl)C=C1)C2CCN(C3=NC(N)=NN3)CC2
Biological Activity: OAT-177 is a potent dual inhibitor targeting acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT1) with an IC50=14.2 nM for human AMCase and IC50=232 nM for human CHIT1. OAT-177 is promising for research of chronic inflammatory and fibrotic-related lung diseases such as asthma and idiopathic pulmonary fibrosis[1].
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OAT-177 | 99.90% | OAT-177 is a potent dual inhibitor targeting acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT1) with an IC50=14.2 nM for human AMCase and IC50=232 nM for human CHIT1. OAT-177 is promising for research of chronic inflammatory and fibrotic-related lung diseases such as asthma and idiopathic pulmonary fibrosis. | ||||||||||||||||||||
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Keywords
