1808918-69-5
1808918-69-5
Chemical Structure
Fazamorexant
Synonym(s): YZJ-1139
- CAS No.: 1808918-69-5
- Formula:C25H25FN4O2
- Molecular Weight:432.49
IUPAC Name: diisobutyl maleate
InChIKey: PMJPLAGTPPVSRL-JLMWRMLUSA-N
SMILES: O=C(C1=C(C2=NC=CC=N2)C=CC(C)=C1)N3[C@]4([H])[C@@H](CC[C@@]3([H])CC4)COC5=CC=C(C=N5)F
Biological Activity: Fazamorexant (YZJ-1139) is an orally active dual orexin receptor antagonist, with an IC50 of 32 nM against OX1R and an IC50 of 41 nM against OX2R. Fazamorexant prolongs total sleep time and improves sleep efficiency. Fazamorexant is applicable to related research on insomnia[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Fazamorexant | 98.95% | Fazamorexant (YZJ-1139) is an orally active dual orexin receptor antagonist, with an IC50 of 32 nM against OX1R and an IC50 of 41 nM against OX2R. Fazamorexant prolongs total sleep time and improves sleep efficiency. Fazamorexant is applicable to related research on insomnia. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Zhenya Zeng, et al. Development of a Scalable Route with Efficient Stereoisomer Control to YZJ-1139, an Orexin Receptor Antagonist. Organic Process Research & Development 2022 26 (2), 447-457
- [2]. Ni J, et al. Pharmacokinetics, Pharmacodynamic, Safety and Tolerability of Fazamorexant, a Novel Dual Orexin Receptor Antagonist: Report of the First-in-Human Study. Drug Des Devel Ther. 2025;19:5271-5282. Published 2025 Jun 19. [Content Brief]
Keywords
