1821307-11-2
Chemical Structure
Pulrodemstat hydrochloride
Synonym(s): CC-90011 hydrochloride; LSD1-IN-7 hydrochloride
- CAS No.: 1821307-11-2
- Formula:C24H24ClF2N5O2
- Molecular Weight:487.93
InChIKey: ZVQQWNQUGRKYAP-UHFFFAOYSA-N
SMILES: N#CC1=CC=C(C(N=C(N2CCC(N)CC2)N3C)=C(C4=CC=C(OC)C(F)=C4)C3=O)C=C1F.Cl
Biological Activity: Pulrodemstat (CC-90011) hydrochloride is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with an IC50 value of 0.25 nM. Pulrodemstat hydrochloride is less enzymatic inhibition against LSD2, MAO-A, and MAO-B. Pulrodemstat hydrochloride induces acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells differentiation and has potent anticancer activity[1].
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Pulrodemstat hydrochloride | Pulrodemstat (CC-90011) hydrochloride is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with an IC50 value of 0.25 nM. Pulrodemstat hydrochloride is less enzymatic inhibition against LSD2, MAO-A, and MAO-B. Pulrodemstat hydrochloride induces acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells differentiation and has potent anticancer activity. | |||||||||||||||||||||
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Keywords
