1835256-48-8
Chemical Structure
Dersimelagon
Synonym(s): MT-7117
- CAS No.: 1835256-48-8
- Formula:C36H45F4N3O5
- Molecular Weight:675.75
IUPAC Name: 1-(2-((3S,4R)-1-((3R,4R)-1-cyclopentyl-3-fluoro-4-(4-methoxyphenyl)pyrrolidine-3-carbonyl)-4-(methoxymethyl)pyrrolidin-3-yl)-5-(trifluoromethyl)phenyl)piperidine-4-carboxylic acid
InChIKey: MUNWOYRHJPWQNE-GMFUQMJFSA-N
SMILES: O=C(N1C[C@H](C2=C(N3CCC(C(O)=O)CC3)C=C(C(F)(F)F)C=C2)[C@@H](COC)C1)[C@]4([C@H](C5=CC=C(OC)C=C5)CN(C6CCCC6)C4)F
Biological Activity: Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist with EC50 values of 8.16, 3.91, 1.14 and 0.251 nM for human (h), cynomolgus monkey (cm), mouse (m) and rat (r) MC1R, respectively. Dersimelagon shows good affinity for hMC1R and hMC4R with Ki values of 2.26, 32.9 nM, respectively. Dersimelagon can be used for the research of skin pigmentation[1][2].
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Dersimelagon | 98.10% | Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist with EC50 values of 8.16, 3.91, 1.14 and 0.251 nM for human (h), cynomolgus monkey (cm), mouse (m) and rat (r) MC1R, respectively. Dersimelagon shows good affinity for hMC1R and hMC4R with Ki values of 2.26, 32.9 nM, respectively. Dersimelagon can be used for the research of skin pigmentation. | ||||||||||||||||||||
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Keywords
