1897406-94-8
Chemical Structure
S1PL-IN- 2
- CAS No.: 1897406-94-8
- Formula:C26H33N3O3
- Molecular Weight:435.56
IUPAC Name: N-(2-((4-butoxy-2,5-dimethylbenzyl)amino)-1-phenylethyl)-5-methylisoxazole-3-carboxamide
InChIKey: UCUNHQRXMTUEQY-UHFFFAOYSA-N
SMILES: O=C(C1=NOC(C)=C1)NC(C2=CC=CC=C2)CNCC3=CC(C)=C(OCCCC)C=C3C
Biological Activity: S1PL-IN-2 (Compound 28) is a potent sphingosine-1-phosphate lyase (S1PL) inhibitor with an IC50 of 120 nM. S1PL-IN-2 shows an IC50 of 230 nM on HEK293 cells. S1PL-IN-2 block the conversion of Vitamin B6 into the active pyridoxal-4-phosphate cofactor required for S1P lyase activity. S1PL-IN-2 can be used for the researches of inflammation and immunology, such as rheumatoid arthritis[1].
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S1PL-IN- 2 | S1PL-IN-2 (Compound 28) is a potent sphingosine-1-phosphate lyase (S1PL) inhibitor with an IC50 of 120 nM. S1PL-IN-2 shows an IC50 of 230 nM on HEK293 cells. S1PL-IN-2 block the conversion of Vitamin B6 into the active pyridoxal-4-phosphate cofactor required for S1P lyase activity. S1PL-IN-2 can be used for the researches of inflammation and immunology, such as rheumatoid arthritis. | |||||||||||||||||||||
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Keywords
