191594-64-6
191594-64-6
Chemical Structure
CGP-75355
- CAS No.: 191594-64-6
- Formula:C39H53N5O7
- Molecular Weight:703.87
IUPAC Name: methyl ((5S,10S,11S,14S)-8-([1,1'-biphenyl]-4-ylmethyl)-11-benzyl-5-(tert-butyl)-10-hydroxy-15,15-dimethyl-3,6,13-trioxo-2-oxa-4,7,8,12-tetraazahexadecan-14-yl)carbamate
InChIKey: UZZKRELETVORAI-UYEZAFAQSA-N
SMILES: CC(C)(C)[C@@H](C(N[C@@H](CC1=CC=CC=C1)[C@@H](O)CN(NC([C@H](C(C)(C)C)NC(OC)=O)=O)CC2=CC=C(C3=CC=CC=C3)C=C2)=O)NC(OC)=O
Biological Activity: CGP-75355 is an inhibitor of HIV-1 protease with IC50 of 26 nM. CGP-75355 is a bis(L-tert-leucine) derivative[1][2].
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CGP-75355 | CGP-75355 is an inhibitor of HIV-1 protease with IC50 of 26 nM. CGP-75355 is a bis(L-tert-leucine) derivative. | |||||||||||||||||||||
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References
- [1]. Bold, G., et al., (1998). New aza-dipeptide analogues as potent and orally absorbed HIV-1 protease inhibitors: candidates for clinical development. Journal of medicinal chemistry, 41(18), 3387-3401. [Content Brief]
- [2]. Wieslaw M. Kazmierski, (2011). Antiviral Drugs: From Basic Discovery Through Clinical Trials.
Keywords
