198968-25-1
Chemical Structure
Org 34167 (freebase)
- CAS No.: 198968-25-1
- Formula:C17H16N2O
- Molecular Weight:264.32
InChIKey: AYDSLXXUAYWCBG-HNNXBMFYSA-N
SMILES: N[C@H](C1=C(C=CC=C1)C2=NOC3=CC=CC=C23)CC=C
Biological Activity: Org 34167 freebase is a blood-brain barrier permeable HCN channel modulator. Org 34167 freebase possesses high Caco-2 cell permeability. Org 34167 freebase modulates HCN channel function to alter activation properties and suppress neuronal hyperexcitability. Org 34167 freebase induces tremors in mice at specific doses. Org 34167 freebase acts as a research tool for studies on developmental and epileptic encephalopathies as well as depression[1][2][3].
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Org 34167 (freebase) | Org 34167 freebase is a blood-brain barrier permeable HCN channel modulator. Org 34167 freebase possesses high Caco-2 cell permeability. Org 34167 freebase modulates HCN channel function to alter activation properties and suppress neuronal hyperexcitability. Org 34167 freebase induces tremors in mice at specific doses. Org 34167 freebase acts as a research tool for studies on developmental and epileptic encephalopathies as well as depression. | |||||||||||||||||||||
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- [1]. Bleakley LE, et al. Org 34167 rescues voltage dependence of mutant channels and normalizes hyperexcitability in HCN1 epilepsy. Epilepsia. 2025;66(12):5082-5095. [Content Brief]
- [2]. McKenzie CE, et al. The Potential Antidepressant Compound Org 34167 Modulates HCN Channels Via a Novel Mode of Action. Mol Pharmacol. 2023;104(2):62-72. [Content Brief]
- [3]. Faassen F, et al. Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003;263(1-2):113-122. [Content Brief]
Keywords
