2019223-60-8
Chemical Structure
CPL302-253
- CAS No.: 2019223-60-8
- Formula:C26H34N8O
- Molecular Weight:474.60
InChIKey: ZIOJSHZDBRHNPU-UHFFFAOYSA-N
SMILES: CC(C)(C)N(CC1)CCN1CC2=NN(C(N3CCOCC3)=C4)C(N=C4C5=C6C=CNC6=CN=C5)=C2
Biological Activity: CPL302-253 is a PI3Kδ inhibitor with an IC50 of 12.20 nM and a human Kd of 0.85 nM. CPL302-253 functionally regulates PI3Kδ activity, blocks the production of IFNγ, IL-33 and ROS in immune cells, and affects immune function. CPL302-253 blocks the progression of asthma-inducing inflammatory responses in a mouse model of asthma. CPL302-253 can be used for research related to asthma[1].
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CPL302-253 | CPL302-253 is a PI3Kδ inhibitor with an IC50 of 12.20 nM and a human Kd of 0.85 nM. CPL302-253 functionally regulates PI3Kδ activity, blocks the production of IFNγ, IL-33 and ROS in immune cells, and affects immune function. CPL302-253 blocks the progression of asthma-inducing inflammatory responses in a mouse model of asthma. CPL302-253 can be used for research related to asthma. | |||||||||||||||||||||
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Keywords
