2022961-17-5
Chemical Structure
Raphin1
- CAS No.: 2022961-17-5
- Formula:C8H8Cl2N4
- Molecular Weight:231.08
IUPAC Name: (E)-2-(2,3-dichlorobenzylidene)hydrazine-1-carboximidamide
InChIKey: WLTSTDGGFCQWTK-YIXHJXPBSA-N
SMILES: N=C(N/N=C/C1=CC=CC(Cl)=C1Cl)N.[(E)]
Biological Activity: Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease[1].
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Raphin1 | 99.74% | Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease. | ||||||||||||||||||||
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Keywords
