202342-22-1
202342-22-1
Chemical Structure
AMG2504
- CAS No.: 202342-22-1
- Formula:C15H10Cl4N2O3S
- Molecular Weight:440.13
IUPAC Name: 4-nitro-N-(2,2,2-trichloro-1-((4-chlorophenyl)thio)ethyl)benzamide
InChIKey: DNTIPHKVCXUYRM-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C([N+]([O-])=O)C=C1)NC(C(Cl)(Cl)Cl)SC2=CC=C(C=C2)Cl
Biological Activity: AMG2504 is a TRPA1 antagonist with an IC50 value of 35 nM against human TRPA1. AMG2504 inhibits human TRPA1 activation induced by AITC and noxious cold stimulation. AMG2504 is applicable to research related to chronic pain[1][2].
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AMG2504 | AMG2504 is a TRPA1 antagonist with an IC50 value of 35 nM against human TRPA1. AMG2504 inhibits human TRPA1 activation induced by AITC and noxious cold stimulation. AMG2504 is applicable to research related to chronic pain. | |||||||||||||||||||||
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References
- [1]. Tanner MR, et al. Differences in ion channel phenotype and function between humans and animal models. Front Biosci (Landmark Ed). 2018;23(1):43-64. Published 2018 Jan 1. [Content Brief]
- [2]. Eid SR. Therapeutic targeting of TRP channels--the TR(i)P to pain relief. Curr Top Med Chem. 2011;11(17):2118-30. [Content Brief]
Keywords
