202656-49-3
Chemical Structure
RIG 200
- CAS. Nr.: 202656-49-3
- Formula:C21H31N3O12S
- Molecular Weight:549.55
IUPAC Name: (2S,3R,4R,5S,6R)-3-((S)-2-acetamido-3-methyl-3-(nitrosothio)butanamido)-6-(acetoxymethyl)tetrahydro-2H-pyran-2,4,5-triyl triacetate
InChIKey: VISYVRBZWPNIOD-GFJCLWMYSA-N
SMILES: CC(O[C@@H]1[C@H]([C@@H](O[C@H](COC(C)=O)[C@H]1OC(C)=O)OC(C)=O)NC([C@H](NC(C)=O)C(C)(C)SN=O)=O)=O
Biological Activity: RIG 200 is an S-nitrosothiol nitric oxide (NO) donor. RIG 200 releases NO through decomposition, activating guanylate cyclase (sGCM) in vascular smooth muscle cells, increasing cGMP levels, and leading to vasodilation. RIG 200 significantly inhibits Collagen (HY-NP003)-induced platelet aggregation in platelet-rich plasma (PRP). RIG 200 may be used in research on antithrombus[1][2][3].
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RIG 200 | RIG 200 is an S-nitrosothiol nitric oxide (NO) donor. RIG 200 releases NO through decomposition, activating guanylate cyclase (sGCM) in vascular smooth muscle cells, increasing cGMP levels, and leading to vasodilation. RIG 200 significantly inhibits Collagen (HY-NP003)-induced platelet aggregation in platelet-rich plasma (PRP). RIG 200 may be used in research on antithrombus. | |||||||||||||||||||||
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- [1]. Megson IL, et al. Inhibition of human platelet aggregation by a novel S-nitrosothiol is abolished by haemoglobin and red blood cells in vitro: implications for anti-thrombotic therapy. Br J Pharmacol. 2000 Dec;131(7):1391-8. [Content Brief]
- [2]. Sogo N, et al. S-nitrosothiols cause prolonged, nitric oxide-mediated relaxation in human saphenous vein and internal mammary artery: therapeutic potential in bypass surgery. Br J Pharmacol. 2000 Nov;131(6):1236-44. [Content Brief]
- [3]. Sogo N, et al. A novel S-nitrosothiol (RIG200) causes prolonged relaxation in dorsal hand veins with damaged endothelium. Clin Pharmacol Ther. 2000 Jul;68(1):75-81. [Content Brief]
Keywords
