207862-44-0
Chemical Structure
KW-2170 hydrochloride
- CAS No.: 207862-44-0
- Formula:C20H25Cl2N5O4
- Molecular Weight:470.35
IUPAC Name: 5-((3-aminopropyl)amino)-7,10-dihydroxy-2-(((2-hydroxyethyl)amino)methyl)-6H-pyrazolo[4,5,1-de]acridin-6-one dihydrochloride
InChIKey: VPJUIFWAPQSXSP-UHFFFAOYSA-N
SMILES: O=C1C2=C(C(O)=CC=C2O)N(N=C3CNCCO)C4=C3C=CC(NCCCN)=C14.Cl.Cl
Biological Activity: KW-2170 hydrochloride is an alkylating agent and topoisomerase II inhibitor. KW-2170 hydrochloride stabilizes the topoisomerase II-DNA complex, causing DNA double-strand breaks, thereby preventing DNA replication and transcription, and ultimately leading to the death of tumor cells. KW-2170 hydrochloride exhibits potent and broad-spectrum anti-tumor activity in various mouse and human tumor models. KW-2170 hydrochloride can be used in the research of solid tumors[1][2].
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KW-2170 hydrochloride | KW-2170 hydrochloride is an alkylating agent and topoisomerase II inhibitor. KW-2170 hydrochloride stabilizes the topoisomerase II-DNA complex, causing DNA double-strand breaks, thereby preventing DNA replication and transcription, and ultimately leading to the death of tumor cells. KW-2170 hydrochloride exhibits potent and broad-spectrum anti-tumor activity in various mouse and human tumor models. KW-2170 hydrochloride can be used in the research of solid tumors. | |||||||||||||||||||||
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Keywords
