2084834-44-4
Chemical Structure
SLL-022CCP
- CAS No.: 2084834-44-4
- Formula:C31H34N2O4
- Molecular Weight:498.61
InChIKey: DXOQUNRDOKHZKA-TYGDBYJPSA-N
SMILES: O=C(C1=C(N)C=CC=C1)[C@@H]2[C@@](C=C3)(OC)[C@H]4[C@]5(CC6)C7=C(O4)C(OC)=CC=C7CC(N6CC8CC8)[C@@]53C2
Biological Activity: SLL-022CCP is a KOR-selective, high affinity and extremely potent agonist with an EC50 of 9.1 nM and a Ki of 2.0 nM. SLL-022CCP inhibits cAMP production with an EC50 of 0.002 nM, and exhibits high receptor subtype selectivity over the μ-opioid receptor (MOR, EC50 = 1.6 nM) and δ-opioid receptor (DOR, EC50 = 30.0 nM). SLL-022CCP exhibits robust antinociceptive and antipruritic effects with low central side effects[1].
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SLL-022CCP | SLL-022CCP is a KOR-selective, high affinity and extremely potent agonist with an EC50 of 9.1 nM and a Ki of 2.0 nM. SLL-022CCP inhibits cAMP production with an EC50 of 0.002 nM, and exhibits high receptor subtype selectivity over the μ-opioid receptor (MOR, EC50 = 1.6 nM) and δ-opioid receptor (DOR, EC50 = 30.0 nM). SLL-022CCP exhibits robust antinociceptive and antipruritic effects with low central side effects. | |||||||||||||||||||||
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Keywords
