2093088-81-2
Chemical Structure
FIIN-4
- CAS No.: 2093088-81-2
- Formula:C35H38N8O4
- Molecular Weight:634.73
IUPAC Name: N-(3-((3-(3,5-dimethoxyphenyl)-7-((4-(4-methylpiperazin-1-yl)phenyl)amino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)methyl)phenyl)acrylamide
InChIKey: NQUHMXJRVOMTBY-UHFFFAOYSA-N
SMILES: O=C1N(C2=NC(NC3=CC=C(C=C3)N4CCN(CC4)C)=NC=C2CN1C5=CC(OC)=CC(OC)=C5)CC6=CC=CC(NC(C=C)=O)=C6
Biological Activity: FIIN-4 is a first-in-class, orally active and covalent FGFR inhibitor with IC50s of 2.6 nM, 2.6 nM, 5.6 nM, 9.2 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. FIIN-4 can inhibit metastatic tumor growth.
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FIIN-4 | FIIN-4 is a first-in-class, orally active and covalent FGFR inhibitor with IC50s of 2.6 nM, 2.6 nM, 5.6 nM, 9.2 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. FIIN-4 can inhibit metastatic tumor growth. | |||||||||||||||||||||
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Keywords
