2095417-40-4
Chemical Structure
3’-Azido-3’-deoxy-5-fluoro-beta-L-uridine
- CAS No.: 2095417-40-4
- Formula:C9H10FN5O5
- Molecular Weight:287.20
IUPAC Name: 1-((2S,3S,4R,5R)-4-azido-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione
InChIKey: AWEWMNDSGXRWGS-TYQACLPBSA-N
SMILES: O[C@H]1[C@@H](N=[N+]=[N-])[C@H](CO)O[C@@H]1N2C=C(F)C(NC2=O)=O
Biological Activity: 3’-Azido-3’-deoxy-5-fluoro-beta-L-uridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 3’-Azido-3’-deoxy-5-fluoro-beta-L-uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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3’-Azido-3’-deoxy-5-fluoro-beta-L-uridine | 3’-Azido-3’-deoxy-5-fluoro-beta-L-uridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-Azido-3’-deoxy-5-fluoro-beta-L-uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | |||||||||||||||||||||
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