2121515-37-3
2121515-37-3
Chemical Structure
c-Kit-IN-2
- CAS No.: 2121515-37-3
- Formula:C25H29N9O2S
- Molecular Weight:519.62
IUPAC Name: 1-(5-ethylisoxazol-3-yl)-3-(4-(2-((6-(4-ethylpiperazin-1-yl)pyrimidin-4-yl)amino)thiazol-5-yl)phenyl)urea
InChIKey: YRQLHEOCJDBHLJ-UHFFFAOYSA-N
SMILES: CCN1CCN(C2=CC(NC3=NC=C(C4=CC=C(NC(NC5=NOC(CC)=C5)=O)C=C4)S3)=NC=N2)CC1
Biological Activity: c-Kit-IN-2 is a c-KIT inhibitor with an IC50 of 82 nM, shows superior antiproliferative activities against all the three GIST cell lines, GIST882, GIST430, and GIST48, with GI50s of 3, 1, and 2 nM, respectively[1].
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c-Kit-IN-2 | c-Kit-IN-2 is a c-KIT inhibitor with an IC50 of 82 nM, shows superior antiproliferative activities against all the three GIST cell lines, GIST882, GIST430, and GIST48, with GI50s of 3, 1, and 2 nM, respectively. | |||||||||||||||||||||
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References
Keywords
