2133007-20-0
2133007-20-0
Chemical Structure
p38α-IN-9
- CAS No.: 2133007-20-0
- Formula:C27H24FN3O3
- Molecular Weight:457.50
InChIKey: SBUOAPYCHJMYIZ-UHFFFAOYSA-N
SMILES: CNC(C1=CC=C2C(C(C(C=CC(NC3=CC=C(F)C(NC(C4CC4)=O)=C3)=C5)=C5CC2)=O)=C1)=O
Biological Activity: p38α-IN-9 (Compound 2015) is a p38α inhibitor and blocks p38α’s enzymatic activity with an IC50 lower than 20 nM. p38α-IN-9 inhibits MK2T334 phosphorylation. p38α-IN-9 activates Cdc25b and Cdc25c and simultaneously inactivates Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy and DNA damage. p38α-IN-9 Inhibits colorectal cancer (CRC) metastasis[1].
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p38α-IN-9 | p38α-IN-9 (Compound 2015) is a p38α inhibitor and blocks p38α’s enzymatic activity with an IC50 lower than 20 nM. p38α-IN-9 inhibits MK2T334 phosphorylation. p38α-IN-9 activates Cdc25b and Cdc25c and simultaneously inactivates Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy and DNA damage. p38α-IN-9 Inhibits colorectal cancer (CRC) metastasis. | |||||||||||||||||||||
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References
Keywords
