2170562-35-1
Chemical Structure
AS2030680
- CAS No.: 2170562-35-1
- Formula:C17H13BrF3N3O2
- Molecular Weight:428.20
InChIKey: QQZNNQKAKNVZAY-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=C(OCC=C2C3=C(F)C=C(F)C=C3F)C=C1)NC(N)=N.Br
Biological Activity: AS2030680 is a blood-brain barrier-permeable, orally active 5-HT5A receptor antagonist. AS2030680 regulates 5-HT5A-related downstream signaling pathways, reduces the frequency of tumorsphere-initiating cells in breast cancer cells, and exerts procognitive activity in animal models. AS2030680 can be used to study cognitive impairments associated with dementia and schizophrenia, as well as breast cancer[1][2][3].
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AS2030680 | AS2030680 is a blood-brain barrier-permeable, orally active 5-HT5A receptor antagonist. AS2030680 regulates 5-HT5A-related downstream signaling pathways, reduces the frequency of tumorsphere-initiating cells in breast cancer cells, and exerts procognitive activity in animal models. AS2030680 can be used to study cognitive impairments associated with dementia and schizophrenia, as well as breast cancer. | |||||||||||||||||||||
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- [1]. Yamazaki M, et al. Novel 5-HT5A receptor antagonists ameliorate scopolamine-induced working memory deficit in mice and reference memory impairment in aged rats. J Pharmacol Sci. 2015 Mar;127(3):362-9. [Content Brief]
- [2]. Gwynne WD, et al. Antagonists of the serotonin receptor 5A target human breast tumor initiating cells. BMC Cancer. 2020;20(1):724. Published 2020 Aug 5. [Content Brief]
- [3]. Garay RP, et al. Potential serotonergic agents for the treatment of schizophrenia. Expert Opin Investig Drugs. 2016;25(2):159-170. [Content Brief]
Keywords
