2190-25-2
Chemical Structure
(Z)-2-(Oleoyloxy)propane-1,3-diyl dipalmitate
Synonym(s): 1,3-Dipalmitoyl-2-oleoylglycerol; ?1,3-Palmitin-2-Olein; TG(16:0/18:1/16:0)
- CAS No.: 2190-25-2
- Formula:C53H100O6
- Molecular Weight:833.38
IUPAC Name: 2-(oleoyloxy)propane-1,3-diyl dipalmitate
InChIKey: FDCOHGHEADZEGF-QPLCGJKRSA-N
SMILES: CCCCCCCC/C=C\CCCCCCCC(OC(COC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)=O
Biological Activity: (Z)-2-(Oleoyloxy) propane-1,3-diyl dipalmitate (1,3-Dipalmitoyl-2-oleoylglycerol) is an orally active PTP1B inhibitor with an IC50 of 31.01 μM and a Ki of 16.36 μM. (Z)-2-(Oleoyloxy) propane-1,3-diyl dipalmitate also inhibits α-glucosidase with an IC50 of 163.31 μM. It inhibits phosphorylation of p38 MAPK, activates the PI3K/Akt/CREB pathway, and exhibits antioxidant, anti-apoptosis and anti-inflammatory activities, as well as inhibits peroxynitrite-mediated albumin nitration. (Z)-2-(Oleoyloxy) propane-1,3-diyl dipalmitate can be used in studies related to cerebral ischemia-reperfusion injury and diabetes[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(Z)-2-(Oleoyloxy)propane-1,3-diyl dipalmitate | 98.01% | (Z)-2-(Oleoyloxy) propane-1,3-diyl dipalmitate (1,3-Dipalmitoyl-2-oleoylglycerol) is an orally active PTP1B inhibitor with an IC50 of 31.01 μM and a Ki of 16.36 μM. (Z)-2-(Oleoyloxy) propane-1,3-diyl dipalmitate also inhibits α-glucosidase with an IC50 of 163.31 μM. It inhibits phosphorylation of p38 MAPK, activates the PI3K/Akt/CREB pathway, and exhibits antioxidant, anti-apoptosis and anti-inflammatory activities, as well as inhibits peroxynitrite-mediated albumin nitration. (Z)-2-(Oleoyloxy) propane-1,3-diyl dipalmitate can be used in studies related to cerebral ischemia-reperfusion injury and diabetes. | ||||||||||||||||||||
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- [1]. Lee HK, et al. Neuroprotective Effect of 1,3-dipalmitoyl-2-oleoylglycerol Derived from Rice Bran Oil against Cerebral Ischemia-Reperfusion Injury in Rats. Nutrients. 2022 Mar 25;14(7):1380.
- [2]. Ali MY, et al. Activity-Guided Isolation of sn-1,3-Dipalmitoyl-2-oleoylglycerol as Protein Tyrosine Phosphatase 1B and α-Glucosidase Inhibitor from Skipjack Tuna (Katsuwonus pelamis). Int J Mol Sci. 2026 Aug 1;27(15):6914.
- [3]. Thilakarathna RCN, et al. Mahua oil fraction: A sustainable and functional 1,3-dipalmitoyl-2-oleoylglycerol (POS)-enriched cocoa butter equivalent for chocolate production. Food chemistry. 2025 Jun 15;477:143564.
