2204280-42-0
Chemical Structure
MY33-3 hydrochloride
- CAS No.: 2204280-42-0
- Formula:C16H14ClF6NS2
- Molecular Weight:433.86
IUPAC Name: bis(4-((trifluoromethyl)thio)benzyl)amine hydrochloride
InChIKey: NCXYCGGCHBSQDC-UHFFFAOYSA-N
SMILES: FC(F)(SC1=CC=C(CNCC2=CC=C(C=C2)SC(F)(F)F)C=C1)F.Cl
Biological Activity: MY33-3 hydrochloride is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, with an IC50 of ~0.1 μM. MY33-3 hydrochloride also inhibits PTP-1B (IC50 ~0.7 μM). MY33-3 hydrochloride can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction[1][2][3].
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MY33-3 hydrochloride | 99.32% | MY33-3 hydrochloride is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, with an IC50 of ~0.1 μM. MY33-3 hydrochloride also inhibits PTP-1B (IC50 ~0.7 μM). MY33-3 hydrochloride can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction. | ||||||||||||||||||||
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- [1]. Fernández-Calle R, et, al. Pharmacological inhibition of Receptor Protein Tyrosine Phosphatase β/ζ (PTPRZ1) modulates behavioral responses to ethanol. Neuropharmacology. 2018 Jul 15;137:86-95. [Content Brief]
- [2]. Fernández-Calle R, et, al. Role of RPTPβ/ζ in neuroinflammation and microglia-neuron communication. Sci Rep. 2020 Nov 20;10(1):20259. [Content Brief]
- [3]. Mao S, et, al. Pleiotrophin Potentiates Sevoflurane Anesthesia-induced Learning Deficits in Mice. J Mol Neurosci. 2022 Jan;72(1):48-55. [Content Brief]
Keywords
