220725-87-1
Chemical Structure
EGIS-8332
- CAS No.: 220725-87-1
- Formula:C20H18N4O3
- Molecular Weight:362.38
IUPAC Name: 7-acetyl-5-(4-aminophenyl)-8-methyl-8,9-dihydro-7H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d][1,2]diazepine-8-carbonitrile
InChIKey: CBHCOCUJJQDHSR-UHFFFAOYSA-N
SMILES: CC(N1C(CC2=CC3=C(OCO3)C=C2C(C4=CC=C(N)C=C4)=N1)(C)C#N)=O
Biological Activity: EGIS-8332 is a non-competitive AMPA receptor antagonist. EGIS-8332 inhibits AMPA currents in rat cerebellar Purkinje cells and inhibited the AMPA- and Quisqualate-induced excitotoxicity in primary cultures of telencephalon neurons (IC50 = 5.1-9.0 μM). EGIS-8332 exhibits anticonvulsant and neuroprotective effects. EGIS-8332 can be used for the research of neurological disease[1].
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EGIS-8332 | EGIS-8332 is a non-competitive AMPA receptor antagonist. EGIS-8332 inhibits AMPA currents in rat cerebellar Purkinje cells and inhibited the AMPA- and Quisqualate-induced excitotoxicity in primary cultures of telencephalon neurons (IC50 = 5.1-9.0 μM). EGIS-8332 exhibits anticonvulsant and neuroprotective effects. EGIS-8332 can be used for the research of neurological disease. | |||||||||||||||||||||
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Keywords
