2222354-57-4

HG-12-6 Chemical Structure
2222354-57-4

Chemical Structure

HG-12-6

  • CAS. Nr.: 2222354-57-4
  • Formula:C29H27F3N6O2S
  • Molecular Weight:580.62

IUPAC Name: 3-(2-(cyclopropanecarboxamido)thiazolo[5,4-b]pyridin-5-yl)-N-(4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl)benzamide

InChIKey: BBTDRPBKISKELY-UHFFFAOYSA-N

SMILES: O=C(NC1=CC=C(CN2CCNCC2)C(C(F)(F)F)=C1)C3=CC=CC(C4=CC=C5C(SC(NC(C6CC6)=O)=N5)=N4)=C3

Biological Activity: HG-12-6 is a type II inhibitor of IRAK4. HG-12-6 shows preferential binding to unphosphorylated inactive IRAK4 with an IC50 of 165 nM. HG-12-6 can modulate IRAK4 activity in autoimmunity and inflammation[1].

Art. -Nr. Produktname Reinheit Beschreibung Pricing
HY-123956 		HG-12-6 HG-12-6 is a type II inhibitor of IRAK4. HG-12-6 shows preferential binding to unphosphorylated inactive IRAK4 with an IC50 of 165 nM. HG-12-6 can modulate IRAK4 activity in autoimmunity and inflammation.
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