2228052-38-6
2228052-38-6
Chemical Structure
A-1248767
- CAS No.: 2228052-38-6
- Formula:C47H55N7O6
- Molecular Weight:813.98
InChIKey: KXIBIVGXSKSQOT-UHFFFAOYSA-N
SMILES: O=C(N(C)C)N(CC1)CCN1C2=CC=C(OCC3=NN(C)C(C)=C3C4=C(N(CCN5CCOCC5)C(C(O)=O)=C6CCCOC7=C(C=CC=C8)C8=CC=C7)C6=CC=C4)C=C2
Biological Activity: A-1248767 is a MCL-1 inhibitor (IC50=23.9 nM; Ki=0.41 nM) with anticancer activity. A-1248767, a derivative of A-1210477 (HY-12468), binds to MCL-1 with high affinity, induces the increase of intracellular MCL-1 protein, and promotes tumor cell apoptosis[1].
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A-1248767 | A-1248767 is a MCL-1 inhibitor (IC50=23.9 nM; Ki=0.41 nM) with anticancer activity. A-1248767, a derivative of A-1210477 (HY-12468), binds to MCL-1 with high affinity, induces the increase of intracellular MCL-1 protein, and promotes tumor cell apoptosis. | |||||||||||||||||||||
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References
Keywords
