2241-90-9
Chemical Structure
Cyclobuxine D
- CAS No.: 2241-90-9
- Formula:C25H42N2O
- Molecular Weight:386.61
IUPAC Name: (2aR,3S,4R,5aS,5bS,7aR,9S,11aR,12aS)-2a,5a-dimethyl-9-(methylamino)-3-((S)-1-(methylamino)ethyl)-8-methylenetetradecahydro-1H,12H-cyclopenta[a]cyclopropa[e]phenanthren-4-ol
InChIKey: BSNZFQANPMIOIU-WZBMPAQFSA-N
SMILES: C[C@]12[C@@]3([H])[C@@]4(CC[C@@]1([C@]([C@H](C)NC)([H])[C@H](O)C2)C)[C@@]5([C@@](C([C@@H](NC)CC5)=C)([H])CC3)C4
Biological Activity: Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclobuxine D has a significant bradycardic effect in the rat heart and an inhibitory action on acetylcholine and Ba++−induced contraction of the longitudinal muscle isolated from the rabbit jejunum[1][2].
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Cyclobuxine D | Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclobuxine D has a significant bradycardic effect in the rat heart and an inhibitory action on acetylcholine and Ba++−induced contraction of the longitudinal muscle isolated from the rabbit jejunum. | |||||||||||||||||||||
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- [1]. . A. Eshonov, et al. Alkaloids of Buxus sempervirens, Crystal and Molecular Structure of Cyclobuxine-D and Imperialine. Chemistry of Natural Compounds. 12 January 2014. 49:11791182.
- [2]. Kwon, Jun-Tack, et al. Effects of Cyclobuxine D on Drug-Induced Contractions of the Isolated Rat Uterine Muscle and Potassium-Activated Calcium Channels in an Intestinal Smooth Muscle. The Korean Journal of Pharmacology. 1988. 24 (1): 103-109.
Keywords
