2241914-86-1
2241914-86-1
Chemical Structure
Aurora kinase-IN-2
- CAS No.: 2241914-86-1
- Formula:C22H18ClN5O3
- Molecular Weight:435.86
IUPAC Name: 4-((3-amino-6-(3,5-dimethylisoxazol-4-yl)pyrazin-2-yl)oxy)-N-(3-chlorophenyl)benzamide
InChIKey: RQMVMSIAPOLUTD-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(Cl)=C1)C2=CC=C(OC3=NC(C4=C(C)ON=C4C)=CN=C3N)C=C2
Biological Activity: Aurora kinase-IN-2 (compound 12Aj) is a potent Aurora kinase inhibitor with IC50 values of 90 and 152 nM for Aurora A and Aurora B. Aurora kinase-IN-2 arrests cell cycle at G2/M phase by regulating cyclin B1 and cdc2. Aurora kinase-IN-2 can be used for cancer research[1].
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Aurora kinase-IN-2 | Aurora kinase-IN-2 (compound 12Aj) is a potent Aurora kinase inhibitor with IC50 values of 90 and 152 nM for Aurora A and Aurora B. Aurora kinase-IN-2 arrests cell cycle at G2/M phase by regulating cyclin B1 and cdc2. Aurora kinase-IN-2 can be used for cancer research. | |||||||||||||||||||||
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References
Keywords
