Aurora kinase-IN-2
Aurora kinase-IN-2 (compound 12Aj) is a potent Aurora kinase inhibitor with IC50 values of 90 and 152 nM for Aurora A and Aurora B. Aurora kinase-IN-2 arrests cell cycle at G2/M phase by regulating cyclin B1 and cdc2. Aurora kinase-IN-2 can be used for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 2241914-86-1
- Formula: C22H18ClN5O3
- Molecular Weight:435.86
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Aurora Kinase Isoforms
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Biological Activity
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Aurora A 90 nM (IC50) |
Aurora B 152 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
1.34 μM
Compound: 12Aj
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Antiproliferative activity against human HeLa cells assessed as cell growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition after 72 hrs by MTT assay
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[PMID: 32035750] |
| HepG2 | IC50 |
7.3 μM
Compound: 12Aj
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Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition after 72 hrs by MTT assay
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[PMID: 32035750] |
| LoVo | IC50 |
1.64 μM
Compound: 12Aj
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Antiproliferative activity against human LoVo cells assessed as cell growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human LoVo cells assessed as cell growth inhibition after 72 hrs by MTT assay
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[PMID: 32035750] |
| U-87MG ATCC | IC50 |
11.5 μM
Compound: 12Aj
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Antiproliferative activity against human U87 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Antiproliferative activity against human U87 cells assessed as cell growth inhibition after 72 hrs by MTT assay
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[PMID: 32035750] |
Aurora kinase-IN-2 (compound 12Aj) (72 hours) has antiproliferative activity with IC50 values of 11.5 μM, 1.34 μM, 7.30 μM and 1.64 μM for U87, HeLa, HepG2 and LoVo tumor cell lines, respectively[1].
Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours) inhibits Aurora A and Aurora B in HeLa cells[1].
Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours; HeLa cells) results in G2/M accumulation by regulating the expression of Cyclin B1 and cdc2[1].
Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours) blocks phosphorylation of Aurora kinases in HeLa cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells
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Concentration:0, 1, 5 and 10 μM
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Incubation Time:24 hours
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Result:Decreased the expression level of Aurora A and B, as well as reduced phosphorylation of Aurora A on Thr288 (p-Thr288) and Aurora B on Thr232 (p-Thr232) in a dose-dependent manner.
Chemical Information
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CAS No. 2241914-86-1
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Molecular Weight 435.86
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Formula C22H18ClN5O3
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SMILES
O=C(NC1=CC=CC(Cl)=C1)C2=CC=C(OC3=NC(C4=C(C)ON=C4C)=CN=C3N)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Aurora kinase-IN-2 Related Classifications
HY-150592 Related Classifications
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