2244035-16-1
Chemical Structure
G907
- CAS No.: 2244035-16-1
- Formula:C26H24ClNO3
- Molecular Weight:433.93
IUPAC Name: (E)-3-(6-(1-(2-chloro-6-cyclopropylphenyl)ethoxy)-4-cyclopropylquinolin-3-yl)acrylic acid
InChIKey: HOMQCLNBKVHZGD-FMIVXFBMSA-N
SMILES: O=C(O)/C=C/C1=C(C2CC2)C3=CC(OC(C4=C(C5CC5)C=CC=C4Cl)C)=CC=C3N=C1
Biological Activity: G907 is a selective antagonist of ATP-binding cassette (ABC) transporter MsbA with anti-microbial activity. G907 inhibits E. coli MsbA with an IC50 value of 18 nM. G907 traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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G907 | 98.06% | G907 is a selective antagonist of ATP-binding cassette (ABC) transporter MsbA with anti-microbial activity. G907 inhibits E. coli MsbA with an IC50 value of 18 nM. G907 traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket. | ||||||||||||||||||||
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Keywords
