2244402-11-5
Chemical Structure
GPC3 targeting peptide 2
- CAS No.: 2244402-11-5
- Formula:C62H96N16O20
- Molecular Weight:1385.52
InChIKey: JDORNGQHBVZKJB-MGIYHICQSA-N
SMILES: O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CC(N)=O)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N
Biological Activity: GPC3 targeting peptide 2 is a glypican-3 (GPC3) targeting peptide that binds specifically to GPC3 with a Kd of 39.5 nM. GPC3 targeting peptide 2 can be conjugated to IRDye800 via a GGGSC linker for near-infrared fluorescence and photoacoustic imaging, with a tumor-to-adjacent liver fluorescence intensity ratio of approximately 2-fold. GPC3 targeting peptide 2 shows high specificity for immunofluorescence staining of HCC specimens. GPC3 targeting peptide 2 can be used in studies related to GPC3-targeted molecular imaging and early detection of hepatocellular carcinoma[1][2].
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GPC3 targeting peptide 2 | GPC3 targeting peptide 2 is a glypican-3 (GPC3) targeting peptide that binds specifically to GPC3 with a Kd of 39.5 nM. GPC3 targeting peptide 2 can be conjugated to IRDye800 via a GGGSC linker for near-infrared fluorescence and photoacoustic imaging, with a tumor-to-adjacent liver fluorescence intensity ratio of approximately 2-fold. GPC3 targeting peptide 2 shows high specificity for immunofluorescence staining of HCC specimens. GPC3 targeting peptide 2 can be used in studies related to GPC3-targeted molecular imaging and early detection of hepatocellular carcinoma. | |||||||||||||||||||||
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- [1]. Feng S, et al. Multi-Modal Imaging Probe for Glypican-3 Overexpressed in Orthotopic Hepatocellular Carcinoma. Journal of medicinal chemistry. 2021 Nov 11;64(21):15639-15650. [Content Brief]
- [2]. Shuo F, et al. A Novel Peptide Multimer Biosensor for Enhanced Imaging and Multivalent Detection of Hepatocellular Carcinoma[J]. Available at SSRN 5188470.
Keywords
