2244671-47-2
Chemical Structure
SARS-CoV-IN-6
- CAS. Nr.: 2244671-47-2
- Formula:C25H29N5O3
- Molecular Weight:447.53
InChIKey: XZXFNKQKBQTDOF-RBUKOAKNSA-N
SMILES: CN1C(N(C)C=C(CNC2=CC=C3N(C[C@H]4C[C@@H]3CN(CC5=CC=CC=C5)C4)C2=O)C1=O)=O
Biological Activity: SARS-CoV-IN-6 (Compound 17) is an inhibitor of SARS-CoV-1 and SARS-CoV-2 RdRp, with an IC50 value of 7.8 μM against SARS-CoV-2 RdRp. SARS-CoV-IN-6 reduces cytopathic effects in cells infected with SARS-CoV-1 and SARS-CoV-2 replicon-based single-round infectious particles (SRIPs), and inhibits SARS-CoV N protein expression, with EC50 values of 0.12 µM for SARS-CoV-1 replicon-based SRIPs and 1.47 µM for SARS-CoV-2 replicon-based SRIPs[1].
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SARS-CoV-IN-6 | SARS-CoV-IN-6 (Compound 17) is an inhibitor of SARS-CoV-1 and SARS-CoV-2 RdRp, with an IC50 value of 7.8 μM against SARS-CoV-2 RdRp. SARS-CoV-IN-6 reduces cytopathic effects in cells infected with SARS-CoV-1 and SARS-CoV-2 replicon-based single-round infectious particles (SRIPs), and inhibits SARS-CoV N protein expression, with EC50 values of 0.12 µM for SARS-CoV-1 replicon-based SRIPs and 1.47 µM for SARS-CoV-2 replicon-based SRIPs. | |||||||||||||||||||||
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Keywords
