2304549-73-1
Chemical Structure
GFB-8438
- CAS No.: 2304549-73-1
- Formula:C16H14ClF3N4O2
- Molecular Weight:386.76
IUPAC Name: 4-chloro-5-(3-oxo-4-(2-(trifluoromethyl)benzyl)piperazin-1-yl)pyridazin-3(2H)-one
InChIKey: MITRKIWBJVJRAM-UHFFFAOYSA-N
SMILES: O=C1CN(C2=C(Cl)C(NN=C2)=O)CCN1CC3=CC=CC=C3C(F)(F)F
Biological Activity: GFB-8438 is a potent and subtype selective TRPC5 inhibitor, with IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively. GFB-8438 shows excellent selectivity against TRPC6, other TRP family members, NaV 1.5, as well as limited activity against the hERG channel. GFB-8438 protects mouse podocytes from injury induced by protamine sulfate model[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GFB-8438 | 99.74% | GFB-8438 is a potent and subtype selective TRPC5 inhibitor, with IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively. GFB-8438 shows excellent selectivity against TRPC6, other TRP family members, NaV 1.5, as well as limited activity against the hERG channel. GFB-8438 protects mouse podocytes from injury induced by protamine sulfate model. | ||||||||||||||||||||
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Keywords
