2305416-04-8
Chemical Structure
3’-Azido-3’-deoxy-3-deazauridine
- CAS No.: 2305416-04-8
- Formula:C10H12N4O5
- Molecular Weight:268.23
IUPAC Name: 1-((2R,3R,4S,5S)-4-azido-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxypyridin-2(1H)-one
InChIKey: NEUBSVDAIXFWBD-PEBGCTIMSA-N
SMILES: OC[C@@H]1[C@@H](N=[N+]=[N-])[C@@H](O)[C@H](N2C(C=C(O)C=C2)=O)O1
Biological Activity: 3’-Azido-3’-deoxy-3-deazauridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 3’-Azido-3’-deoxy-3-deazauridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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3’-Azido-3’-deoxy-3-deazauridine | 3’-Azido-3’-deoxy-3-deazauridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-Azido-3’-deoxy-3-deazauridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | |||||||||||||||||||||
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