2375107-27-8
2375107-27-8
Chemical Structure
Mutated EGFR-IN-3
- CAS No.: 2375107-27-8
- Formula:C31H29FN4O2
- Molecular Weight:508.59
IUPAC Name: 10-benzyl-8-fluoro-2-(4-(4-methylpiperazin-1-yl)phenoxy)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one
InChIKey: ZPNTXOKOIHPCLI-UHFFFAOYSA-N
SMILES: O=C1C2=CC(OC3=CC=C(N4CCN(C)CC4)C=C3)=CC=C2NC5=CC=C(F)C=C5N1CC6=CC=CC=C6
Biological Activity: Mutated EGFR-IN-3 (compound 3) is a potent, ATP-competitive and highly selective allosteric dibenzodiazepinone inhibitor of the EGFR(L858R/T790M) and EGFR(L858R/T790M/C797S) mutants with IC50 values of 12 nM and 13 nM, respectively[1].
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Mutated EGFR-IN-3 | Mutated EGFR-IN-3 (compound 3) is a potent, ATP-competitive and highly selective allosteric dibenzodiazepinone inhibitor of the EGFR(L858R/T790M) and EGFR(L858R/T790M/C797S) mutants with IC50 values of 12 nM and 13 nM, respectively. | |||||||||||||||||||||
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References
Keywords
