2377187-09-0
Chemical Structure
DQP-997-74
- CAS No.: 2377187-09-0
- Formula:C28H19Cl2F2N3O4
- Molecular Weight:570.37
InChIKey: XJZPJUOPCITDPJ-UHFFFAOYSA-N
SMILES: O=C(CC(F)(C(N1N=C(CC1C2=CC=C(C=C2)Cl)C3=C(C4=CC=C(Cl)C=C4)C5=C(C=CC=C5)NC3=O)=O)F)O
Biological Activity: DQP-997-74 (compound 2i) is a selective negative allosteric modulator of N-methyl-d-aspartate receptor (NMDAR), specifically targeting GluN2C/D (IC50: 0.069 μM and 0.035 μM), with blood-brain barrier penetrability. Where DQP refers to dihydroquinoline-pyrazoline. DQP-997-74 acts synergistically with the agonist glutamate to exhibit time-dependent enhanced potency in inhibiting hypersynchronous activity driven by high-frequency excitatory synaptic transmission. DQP-997-74 reduces the number of epileptogenesis in a murine model of tuberous sclerosis complex (TSC)-induced epilepsy. DQP-997-74 can be used for research on NMDAR-related neurological diseases[1].
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DQP-997-74 | 99.85% | DQP-997-74 (compound 2i) is a selective negative allosteric modulator of N-methyl-d-aspartate receptor (NMDAR), specifically targeting GluN2C/D (IC50: 0.069 μM and 0.035 μM), with blood-brain barrier penetrability. Where DQP refers to dihydroquinoline-pyrazoline. DQP-997-74 acts synergistically with the agonist glutamate to exhibit time-dependent enhanced potency in inhibiting hypersynchronous activity driven by high-frequency excitatory synaptic transmission. DQP-997-74 reduces the number of epileptogenesis in a murine model of tuberous sclerosis complex (TSC)-induced epilepsy. DQP-997-74 can be used for research on NMDAR-related neurological diseases. | ||||||||||||||||||||
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Keywords
