2378862-90-7
Chemical Structure
Simridarlimab
Synonym(s): IBI-322
- CAS No.: 2378862-90-7
- Formula:N/A
- Molecular Weight:(125.734 kDa)
IUPAC Name: 4-(2-((E)-2-((E)-2-chloro-3-((Z)-2-(1-(4-sulfobutyl)benzo[cd]indol-2(1H)-ylidene)ethylidene)cyclohex-1-en-1-yl)vinyl)benzo[cd]indol-1-ium-1-yl)butane-1-sulfonate
SMILES: [Simridarlimab]
Biological Activity: Simridarlimab (IBI-322) is a bispecific antibody targeting PD-L1 and CD47. Simridarlimab attenuates CD47 activity in monovalent binding and blockes PD-L1 activity in bivalent binding. Simridarlimab selectively binds to CD47+PD-L1+ tumor cells, effectively inhibits CD47-SIRPα signal and triggered strong tumor cell phagocytosis in vitro[1].
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Simridarlimab | 99.81% | Simridarlimab (IBI-322) is a bispecific antibody targeting PD-L1 and CD47. Simridarlimab attenuates CD47 activity in monovalent binding and blockes PD-L1 activity in bivalent binding. Simridarlimab selectively binds to CD47+PD-L1+ tumor cells, effectively inhibits CD47-SIRPα signal and triggered strong tumor cell phagocytosis in vitro. | ||||||||||||||||||||
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Keywords
