2389988-70-7
Chemical Structure
TLR7 agonist 13
- CAS No.: 2389988-70-7
- Formula:C17H19N5O6
- Molecular Weight:389.36
IUPAC Name: ((2S,4R,5R)-4-acetoxy-5-(2-amino-8-oxo-7-(prop-2-yn-1-yl)-7,8-dihydro-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl acetate
InChIKey: OEXMWVBGTNSTSR-NJZAAPMLSA-N
SMILES: O=C1N(CC#C)C2=C(N=C(N)N=C2)N1[C@@H]3O[C@H](COC(C)=O)C[C@H]3OC(C)=O
Biological Activity: TLR7 agonist 13 is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1]. TLR7 agonist 13 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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TLR7 agonist 13 | TLR7 agonist 13 is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7). TLR7 agonist 13 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | |||||||||||||||||||||
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Keywords
