2410053-15-3
2410053-15-3
Chemical Structure
5-HT1A agonist 1
- CAS No.: 2410053-15-3
- Formula:C22H27N5O2
- Molecular Weight:393.48
SMILES: CC1=C2C(CCN(CCN3CCC(C4=NOC5=C4C=CC=C5)CC3)C2=O)=NN1C
Biological Activity: 5-HT1A agonist 1 (Compound Ex.37) is a highly selective 5-HT1a receptor agonist (EC50=0.18 nM). 5-HT1A agonist 1 mimicks serotonin binding to the receptor, promotes postsynaptic membrane hyperpolarization, inhibits neuronal hyperexcitability, and reduces the release of anxiety-related neurotransmitters. 5-HT1A agonist 1 is promising for research of neuropsychiatric diseases[1].
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5-HT1A agonist 1 | 5-HT1A agonist 1 (Compound Ex.37) is a highly selective 5-HT1a receptor agonist (EC50=0.18 nM). 5-HT1A agonist 1 mimicks serotonin binding to the receptor, promotes postsynaptic membrane hyperpolarization, inhibits neuronal hyperexcitability, and reduces the release of anxiety-related neurotransmitters. 5-HT1A agonist 1 is promising for research of neuropsychiatric diseases. | |||||||||||||||||||||
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References
Keywords
