2410081-56-8
2410081-56-8
Chemical Structure
PBA-1105
- CAS No.: 2410081-56-8
- Formula:C39H48N2O6
- Molecular Weight:640.81
InChIKey: KWKXGSARCNKZPU-UHFFFAOYSA-N
SMILES: O=C(CCCC1=CC=CC=C1)NCCOCCOCCOCCNCC2=CC(OCC3=CC=CC=C3)=C(OCC4=CC=CC=C4)C=C2
Biological Activity: PBA-1105 is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1105 selectively binds to exposed hydrophobic regions of misfolded proteins, facilitating their degradation via the autophagic pathway. PBA-1105 increases the autophagic flux of Ub-conjugated aggregates[1].
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PBA-1105 | 99.47% | PBA-1105 is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1105 selectively binds to exposed hydrophobic regions of misfolded proteins, facilitating their degradation via the autophagic pathway. PBA-1105 increases the autophagic flux of Ub-conjugated aggregates. | ||||||||||||||||||||
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References
Keywords
