2411108-21-7
2411108-21-7
Chemical Structure
Anticancer agent 235
- CAS No.: 2411108-21-7
- Formula:C17H13ClN2O
- Molecular Weight:296.75
InChIKey: RJKACWUBQPTQCW-UHFFFAOYSA-N
SMILES: CN1C2=NC3=CC(OC)=CC=C3C2=CC4=C1C=CC(Cl)=C4
Biological Activity: Anticancer agent 235 (Compound 49) is a modulator for PI3K/AKT/mTOR pathway, that promotes the generation of ROS, reduces the mitochondrial membrane potential, and thereby inhibits the proliferation of cancer cells HCT116, Caco-2, AGS and SMMC-772 with IC50 of 0.35-26.9 μM. Anticancer agent 235 arrests the cell cycle at G2/M phase, and induces apoptosis in HCT116[1].
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Anticancer agent 235 | Anticancer agent 235 (Compound 49) is a modulator for PI3K/AKT/mTOR pathway, that promotes the generation of ROS, reduces the mitochondrial membrane potential, and thereby inhibits the proliferation of cancer cells HCT116, Caco-2, AGS and SMMC-772 with IC50 of 0.35-26.9 μM. Anticancer agent 235 arrests the cell cycle at G2/M phase, and induces apoptosis in HCT116. | |||||||||||||||||||||
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References
Keywords
