2411681-92-8
Chemical Structure
Desthiobiotin-PEG3-NHS ester
- CAS No.: 2411681-92-8
- Formula:C23H38N4O9
- Molecular Weight:514.57
IUPAC Name: 2,5-dioxopyrrolidin-1-yl 19-((4R,5S)-5-methyl-2-oxoimidazolidin-4-yl)-14-oxo-4,7,10-trioxa-13-azanonadecanoate
InChIKey: JWHMGEZINQQWSX-ZWKOTPCHSA-N
SMILES: O=C(N[C@H]1C)N[C@@H]1CCCCCC(NCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O)=O
Biological Activity: Desthiobiotin-PEG3-NHS ester is a single-ring, sulfur-free analog of biotin that binds to streptavidin with nearly equal specificity but less affinity than biotin (Kd = 1011 vs. 1015 M, respectively). Consequently, desthiobiotinylated proteins can be eluted readily and specifically from streptavidin affinity resin using mild conditions based on competitive displacement with free biotin.
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Desthiobiotin-PEG3-NHS ester | Desthiobiotin-PEG3-NHS ester is a single-ring, sulfur-free analog of biotin that binds to streptavidin with nearly equal specificity but less affinity than biotin (Kd = 1011 vs. 1015 M, respectively). Consequently, desthiobiotinylated proteins can be eluted readily and specifically from streptavidin affinity resin using mild conditions based on competitive displacement with free biotin. | |||||||||||||||||||||
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Keywords
