2421260-43-5
2421260-43-5
Chemical Structure
PROTAC ERα Degrader-10
- CAS No.: 2421260-43-5
- Formula:C45H49N5O4
- Molecular Weight:723.90
InChIKey: BMBNNENJXSGVDJ-APTBUVIGSA-N
SMILES: CC/C(C1=CC=CC=C1)=C(C2=CC=C(N3CCC(CN4CCN(C5=CC(CN([C@H]6CCC(NC6=O)=O)C7=O)=C7C=C5)CC4)CC3)C=C2)\C8=CC=C(O)C=C8
Biological Activity: PROTAC ERα Degrader-10 is an orally active estrogen receptor α (ERα) PROTAC degrader, with DC50 values of 0.37, 1.1, and 0.47 nM in MCF7, T47D, and CAMA-1 cells, respectively. PROTAC ERα Degrader-10 exhibits significant anti-tumor activity both in vitro and in vivo, and can be used for breast cancer research[1].
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PROTAC ERα Degrader-10 | PROTAC ERα Degrader-10 is an orally active estrogen receptor α (ERα) PROTAC degrader, with DC50 values of 0.37, 1.1, and 0.47 nM in MCF7, T47D, and CAMA-1 cells, respectively. PROTAC ERα Degrader-10 exhibits significant anti-tumor activity both in vitro and in vivo, and can be used for breast cancer research. | |||||||||||||||||||||
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References
Keywords
