2468219-09-0
Chemical Structure
ALK-IN-22
- CAS No.: 2468219-09-0
- Formula:C24H24ClN7O2
- Molecular Weight:477.95
IUPAC Name: 6-((5-chloro-4-((2-(methylcarbamoyl)phenyl)amino)pyrimidin-2-yl)amino)-N,N,2-trimethyl-1H-indole-3-carboxamide
InChIKey: NQJLJKFROUEMTA-UHFFFAOYSA-N
SMILES: O=C(C1=C(C)NC2=C1C=CC(NC3=NC=C(Cl)C(NC4=CC=CC=C4C(NC)=O)=N3)=C2)N(C)C
Biological Activity: ALK-IN-22 (compound I-24) is a potent ALK inhibitor with IC50 values of 2.3, 3.7 and 2.9 nM for ALK, ALKL1196M and ALKG1202R, respectively. ALK-IN-22 down-regulated the phosphorylation of ALK and its downstream proteins. ALK-IN-22 induces apoptosis. ALK-IN-22 can be used for tumor research[1].
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ALK-IN-22 | ALK-IN-22 (compound I-24) is a potent ALK inhibitor with IC50 values of 2.3, 3.7 and 2.9 nM for ALK, ALKL1196M and ALKG1202R, respectively. ALK-IN-22 down-regulated the phosphorylation of ALK and its downstream proteins. ALK-IN-22 induces apoptosis. ALK-IN-22 can be used for tumor research. | |||||||||||||||||||||
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Keywords
