2477606-97-4
Chemical Structure
Aβ-IN-4
- CAS No.: 2477606-97-4
- Formula:C33H43N5O7
- Molecular Weight:621.72
IUPAC Name: ((7S,10S,13S,E)-7-((S)-2-amino-4-methylpentanamido)-10-benzyl-8,11-dioxo-2-oxa-9,12-diaza-1(1,4)-benzenacyclotetradecaphan-4-ene-13-carbonyl)-L-alanine
InChIKey: WHWQWFRRNQORQB-VLNZCUNHSA-N
SMILES: O=C(N[C@@H](CC1=CC=C(OC/C=C/C[C@@H](C(N2)=O)NC([C@@H](N)CC(C)C)=O)C=C1)C(N[C@@H](C)C(O)=O)=O)[C@@H]2CC3=CC=CC=C3
Biological Activity: Aβ-IN-4 (compound 12) is a potent amyloid β (Aβ) inhibitor. Aβ-IN-4 inhibits Aβ42 aggregation. However, Aβ-IN-4 can not alleviate the neurotoxicity of Aβ42 in SH-SY5Y cells. Aβ-IN-4 can not change the aggregation state of Aβ42 into a nontoxic one[1].
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Aβ-IN-4 | Aβ-IN-4 (compound 12) is a potent amyloid β (Aβ) inhibitor. Aβ-IN-4 inhibits Aβ42 aggregation. However, Aβ-IN-4 can not alleviate the neurotoxicity of Aβ42 in SH-SY5Y cells. Aβ-IN-4 can not change the aggregation state of Aβ42 into a nontoxic one. | |||||||||||||||||||||
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Keywords
